https://andards.com/categories/metabolism-and-mtor/ Recent content in Metabolism and mTOR on AndArds Hugo -- gohugo.io en-us Sat, 04 Apr 2026 19:08:00 +0000 https://andards.com/posts/why-sarcopenia-is-the-silent-killer-of-older-adults-and-how-to-prevent-it/ Sat, 04 Apr 2026 19:08:00 +0000 https://andards.com/posts/why-sarcopenia-is-the-silent-killer-of-older-adults-and-how-to-prevent-it/ Sarcopenia, the age-related loss of muscle mass, strength, and function, is a significant yet often overlooked health challenge for older adults. More than just a natural consequence of aging, sarcopenia is a critical factor influencing independence, quality of life, and even longevity. https://andards.com/posts/david-sabatini-and-the-discovery-of-mtor-the-master-switch-of-aging/ Fri, 27 Mar 2026 06:47:00 +0000 https://andards.com/posts/david-sabatini-and-the-discovery-of-mtor-the-master-switch-of-aging/ The Mammalian Target of Rapamycin, or mTOR, stands as a central regulator of cell growth, metabolism, and aging. Its discovery and subsequent elucidation into a complex signaling pathway have profoundly reshaped our understanding of how organisms respond to nutrients and stress. https://andards.com/posts/the-great-protein-debate-peter-attia-vs.-david-sinclair-on-how-much-to-eat/ Fri, 20 Mar 2026 01:54:00 +0000 https://andards.com/posts/the-great-protein-debate-peter-attia-vs.-david-sinclair-on-how-much-to-eat/ The question of optimal protein intake, particularly as we age, sits at the heart of many longevity discussions. Among the most prominent voices in this arena are Dr. Peter Attia and Dr. David Sinclair, both highly respected but with distinct perspectives on how much protein contributes to a long, healthy life. https://andards.com/posts/cycling-protein-and-rapamycin-can-we-have-our-cake-and-eat-it-too/ Fri, 13 Mar 2026 04:43:00 +0000 https://andards.com/posts/cycling-protein-and-rapamycin-can-we-have-our-cake-and-eat-it-too/ The quest for a longer, healthier life often involves navigating complex biological pathways. Two key players in this intricate dance are protein intake and the pharmaceutical rapamycin, both of which influence a central cellular regulator known as mTOR (mammalian Target of Rapamycin). https://andards.com/posts/the-role-of-insulin-resistance-in-accelerated-aging/ Wed, 04 Mar 2026 02:03:00 +0000 https://andards.com/posts/the-role-of-insulin-resistance-in-accelerated-aging/ Insulin resistance, a condition where the body’s cells don’t respond effectively to insulin, plays a significant role in the acceleration of biological aging. This isn’t merely about developing type 2 diabetes; it’s a pervasive metabolic dysfunction that can impact various physiological systems, leading to a faster decline in health and function. https://andards.com/posts/matt-kaeberleins-rapamycin-research-the-most-promising-longevity-drug/ Tue, 24 Feb 2026 19:47:00 +0000 https://andards.com/posts/matt-kaeberleins-rapamycin-research-the-most-promising-longevity-drug/ Rapamycin, an immunosuppressant drug discovered in the 1970s, has garnered significant attention in the longevity research community. Among the key figures exploring its potential to extend healthy lifespan is Dr. Matt Kaeberlein, a professor of laboratory medicine and pathology at the University of Washington. https://andards.com/posts/the-mtor-paradox-why-building-muscle-might-conflict-with-living-longer/ Thu, 19 Feb 2026 06:55:00 +0000 https://andards.com/posts/the-mtor-paradox-why-building-muscle-might-conflict-with-living-longer/ The pursuit of a robust physique and the desire for a long, healthy life often seem to align. Exercise, good nutrition, and strong muscles are commonly associated with vitality and longevity. However, a closer look at the cellular pathways governing growth and repair reveals a nuanced relationship, particularly concerning a central regulator known as mTOR. https://andards.com/posts/ampk-vs.-mtor-the-seesaw-of-cellular-energy-and-aging/ Tue, 20 Jan 2026 05:52:00 +0000 https://andards.com/posts/ampk-vs.-mtor-the-seesaw-of-cellular-energy-and-aging/ The intricate machinery within our cells operates under constant surveillance, managing resources and responding to environmental cues. At the heart of this cellular management are two pivotal pathways: AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR). https://andards.com/posts/eric-verdin-on-ketones-as-signaling-molecules-for-longevity/ Fri, 16 Jan 2026 22:13:00 +0000 https://andards.com/posts/eric-verdin-on-ketones-as-signaling-molecules-for-longevity/ The conversation around longevity often centers on diet and lifestyle, with increasing attention paid to specific metabolic states. Among these, ketosis—a metabolic process where the body primarily burns fat for fuel, producing molecules called ketones—has garnered significant interest. https://andards.com/posts/dudley-lammings-research-on-bcaa-restriction-for-metabolic-health/ Tue, 13 Jan 2026 06:56:00 +0000 https://andards.com/posts/dudley-lammings-research-on-bcaa-restriction-for-metabolic-health/ Dietary restriction, long recognized for its role in health and longevity, now encompasses more targeted approaches than simple calorie reduction. One promising area, branched-chain amino acid (BCAA) restriction, has been significantly advanced by Dr. Dudley Lamming and his team.